Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference
Identifieur interne : 000709 ( Main/Exploration ); précédent : 000708; suivant : 000710Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference
Auteurs : John H. Beigel [États-Unis] ; Hannah H. Nam [États-Unis] ; Peter L. Adams [États-Unis] ; Amy Krafft [États-Unis] ; William L. Ince [États-Unis] ; Samer S. El-Kamary [États-Unis] ; Amy C. Sims [États-Unis]Source :
- Antiviral Research [ 0166-3542 ] ; 2019.
Abstract
The International Society for Influenza and other Respiratory Virus Diseases held its 6th Antiviral Group (isirv-AVG) conference in Rockville, Maryland, November 13–15, 2018. The three-day program was focused on therapeutics towards seasonal and pandemic influenza, respiratory syncytial virus, coronaviruses including MERS-CoV and SARS-CoV, human rhinovirus, and other respiratory viruses. Updates were presented on several influenza antivirals including baloxavir, CC-42344, VIS410, immunoglobulin, immune plasma, MHAA4549A, pimodivir (JNJ-63623872), umifenovir, and HA minibinders; RSV antivirals including presatovir (GS-5806), ziresovir (AK0529), lumicitabine (ALS-008176), JNJ-53718678, JNJ-64417184, and EDP-938; broad spectrum antivirals such as favipiravir, VH244, remdesivir, and EIDD-1931/EIDD-2801; and host directed strategies including nitazoxanide, eritoran, and diltiazem. Other topics included considerations of novel endpoints such as ordinal scales and patient reported outcomes (PRO), and study design issues, and other regulatory considerations for antiviral drug development. The aim of this report is to provide a summary of the presentations given at this meeting.
Url:
DOI: 10.1016/j.antiviral.2019.04.006
PubMed: 30974127
PubMed Central: 7132446
Affiliations:
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Beigel</name><affiliation wicri:level="2"><nlm:aff id="aff1">National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nam, Hannah H" sort="Nam, Hannah H" uniqKey="Nam H" first="Hannah H." last="Nam">Hannah H. Nam</name><affiliation wicri:level="2"><nlm:aff id="aff2">Northwestern University, Feinberg School of Medicine, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwestern University, Feinberg School of Medicine, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Adams, Peter L" sort="Adams, Peter L" uniqKey="Adams P" first="Peter L." last="Adams">Peter L. Adams</name><affiliation wicri:level="2"><nlm:aff id="aff3">Biomedical Advanced Research and Development Authority (BARDA), Office of the Assistant Secretary for Preparedness and Response (ASPR), Department of Health and Human Services (HHS), Washington, DC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Advanced Research and Development Authority (BARDA), Office of the Assistant Secretary for Preparedness and Response (ASPR), Department of Health and Human Services (HHS), Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Krafft, Amy" sort="Krafft, Amy" uniqKey="Krafft A" first="Amy" last="Krafft">Amy Krafft</name><affiliation wicri:level="2"><nlm:aff id="aff1">National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ince, William L" sort="Ince, William L" uniqKey="Ince W" first="William L." last="Ince">William L. Ince</name><affiliation wicri:level="2"><nlm:aff id="aff4">Division of Antiviral Products, Office of Antimicrobial Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Antiviral Products, Office of Antimicrobial Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="El Kamary, Samer S" sort="El Kamary, Samer S" uniqKey="El Kamary S" first="Samer S." last="El-Kamary">Samer S. El-Kamary</name><affiliation wicri:level="2"><nlm:aff id="aff4">Division of Antiviral Products, Office of Antimicrobial Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Antiviral Products, Office of Antimicrobial Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name><affiliation wicri:level="2"><nlm:aff id="aff5">Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The International Society for Influenza and other Respiratory Virus Diseases held its 6th Antiviral Group (isirv-AVG) conference in Rockville, Maryland, November 13–15, 2018. The three-day program was focused on therapeutics towards seasonal and pandemic influenza, respiratory syncytial virus, coronaviruses including MERS-CoV and SARS-CoV, human rhinovirus, and other respiratory viruses. Updates were presented on several influenza antivirals including baloxavir, CC-42344, VIS410, immunoglobulin, immune plasma, MHAA4549A, pimodivir (JNJ-63623872), umifenovir, and HA minibinders; RSV antivirals including presatovir (GS-5806), ziresovir (AK0529), lumicitabine (ALS-008176), JNJ-53718678, JNJ-64417184, and EDP-938; broad spectrum antivirals such as favipiravir, VH244, remdesivir, and EIDD-1931/EIDD-2801; and host directed strategies including nitazoxanide, eritoran, and diltiazem. Other topics included considerations of novel endpoints such as ordinal scales and patient reported outcomes (PRO), and study design issues, and other regulatory considerations for antiviral drug development. 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Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>District de Columbia</li><li>Illinois</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Beigel, John H" sort="Beigel, John H" uniqKey="Beigel J" first="John H." last="Beigel">John H. Beigel</name></region><name sortKey="Adams, Peter L" sort="Adams, Peter L" uniqKey="Adams P" first="Peter L." last="Adams">Peter L. Adams</name><name sortKey="El Kamary, Samer S" sort="El Kamary, Samer S" uniqKey="El Kamary S" first="Samer S." last="El-Kamary">Samer S. El-Kamary</name><name sortKey="Ince, William L" sort="Ince, William L" uniqKey="Ince W" first="William L." last="Ince">William L. Ince</name><name sortKey="Krafft, Amy" sort="Krafft, Amy" uniqKey="Krafft A" first="Amy" last="Krafft">Amy Krafft</name><name sortKey="Nam, Hannah H" sort="Nam, Hannah H" uniqKey="Nam H" first="Hannah H." last="Nam">Hannah H. Nam</name><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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